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Image Search Results
Journal: Nature biotechnology
Article Title: Singling out blood development
doi: 10.1038/nbt.3168
Figure Lengend Snippet: A novel workflow to identify regulatory interactions between genes during a developmental time course based on single-cell analysis, (a) Flk1+ cells are sorted from mouse embryos at four time points and Runx1+ cells from one time point. Expression states of 42 genes are assessed in single cells in these five groups, yielding a multidimensional data set. E, embryonic day.(b) Similarities between individual cells are visualized using a diffusion map.(c) A genetic interaction map is created by the SCNS toolkit. Gene expression is first discretized, and all existing expression states are visualized in a state diagram. Interactions between genes are then visualized as an asynchronous Boolean network model. Hypotheses generated from the model are tested in experiments.
Article Snippet: Single-cell expression states are transformed into regulatory interactions between genes through a pioneering analytic method called the
Techniques: Single-cell Analysis, Expressing, Diffusion-based Assay, Gene Expression, Generated